On December 18, 2025, Anthropic and the US Department of Energy (DOE) announced a multi-year partnership as part of the DOE’s Genesis Mission. The Genesis Mission aims to apply artificial intelligence (AI) to strengthen America’s scientific leadership. This collaboration focuses on three domains: American energy dominance, the biological and life sciences, and scientific productivity, and could influence work across all 17 of the United States’ national laboratories.
Why now and what the partnership seeks to achieve
The Genesis Mission frames the moment as critical: with global competition in AI intensifying, the United States must combine its extensive scientific infrastructure — from supercomputers to decades of experimental data — with cutting-edge AI capabilities to maintain scientific leadership. Anthropic has stated its intention to play a significant role in that effort.
Jared Kaplan, Anthropic’s Chief Science Officer, said: “Anthropic was founded by scientists who believe AI can deliver transformative progress for research itself.” Kaplan described the Genesis Mission as an ambitious, rigorous program where that belief will be tested, and said Anthropic is honored to help advance science that benefits everyone.
Brian Peters, Anthropic's Head of North America Government Affairs, attended the Genesis Mission launch event at the White House. Anthropic said it looks forward to contributing to the mission and continuing collaboration with the DOE.
What Anthropic will provide to DOE researchers
Anthropic intends to give DOE researchers access to its Claude model and to an Anthropic engineering team that can develop purpose-built tools. The announcement lists possible offerings including:
- AI "agents" (models that take actions) to address DOE’s highest-priority challenges,
- Model Context Protocol servers that connect Claude to scientific instruments and tools,
- Claude Skills, specialized expertise modules for relevant scientific workflows.
Focus areas and expected impacts
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Energy dominance: Claude may assist with tasks ranging from accelerating permitting review processes that can bottleneck energy expansion to supporting frontier research in nuclear technology and strengthening domestic energy security.
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Biological and life sciences: Claude could support development of early-warning systems for future pandemics and biological threat detection, and help accelerate drug discovery and development.
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Scientific productivity: the announcement states Claude can access fifty years of DOE research context and use that information to speed up research cycles in strategically important domains, offering well-informed research support such as new ideas to test or patterns in older data that humans might have missed.
Prior collaborations and next steps
Anthropic said this partnership builds on previous projects with the DOE, including co-development of a nuclear risk classifier with the National Nuclear Security Administration and deployments of Claude at the Lawrence Livermore National Laboratory. The partners intend to learn from current work with the DOE to develop models for effective AI–human collaboration and to feed those lessons back into the development of AI tools.
Summary
The multi-year partnership under the Genesis Mission aims to apply Anthropic’s AI capabilities to support US priorities in energy, biological security, and scientific productivity. The collaboration could affect research across all 17 US national laboratories, and expands on earlier joint projects between Anthropic and DOE agencies.
